Benfica president Luis Filipe Vieira is on his way to Manchester to negotiate the transfer of Nelson Semedo and Victor Lindelof, the Daily Star revealed.
The two were key men for Benfica as they were crowned champions in Portugal and are for sale for £83million.
The two defenders would add depth to Jose Mourinho's squad that will feature in next season's Champions League.
Lindelof was already linked with a move to Old Trafford during last January's winter transfer window but he eventually stayed with Benfica.
Back then, he was coy on a possible move to the English Premier League: "I have always focused on what was important to me and that’s the team. They [rumours] make no difference to me.
“As I’ve said I’ve been thriving at Benfica and that’s where the focus has been. A lot has been written and I’ve said nothing, I’ve been focused."