Nick Powell and Victor Valdes have been released by Manchester United, the club has confirmed.
Youngsters George Dorrington and Oliver Rathbone have also left the club.
So far, the Red Devils have added Eric Bertrand Bailly during the summer transfer window but Zlatan Ibrahimovic and Henrikh Mkhitaryan are expected to join him at the start of next month.
"Nick Powell and Victor Valdes are the two first-team players who have been released by Manchester United this summer," the club said in a statement.
"Powell made two substitute appearances under Louis van Gaal last season, coming off the bench against Wolfsburg and Bournemouth in December, before joining Hull City on loan.
"The 22-year-old signed for United from Crewe Alexandra in 2012 and scored on his debut against Wigan Athletic.
"Valdes arrived as a free agent last January and made his bow when replacing injured no.1 David De Gea during the 1-1 draw with Arsenal in May 2015.
"He kept his place for the goalless draw at Hull in the final game of the season. The 34-year-old had a spell on loan at Standard Liege last term, helping the team win the Belgian Cup."