Manchester United executive vice-chairman Ed Woodward is ready to lock horns with football’s ultimate negotiator Daniel Levy in what would be an audacious move for Harry Kane," the Manchester Evening News reports.
The Red Devils decided not to keep Falcao at Old Trafford and are expected to sell Mexico's Javier Hernandez in the summer transfer window.
Veteran striker Robin van Persie is also expected to leave the club with Juventus and Lazio showing interest.
This leaves boss Louis van Gaal with a major headache in the offensive department but also with more than £100m available to strengthen his squad ahead of next season.
And according to Goal.com, United are prepared to put together a package worth up to £50 million and are willing to offer up Javier Hernandez, Nani and Adnan Januzaj in exchange as part of a deal that would see Kane become Britain's most expensive footballer.
Boss Mauricio Pochettino is reluctant to sell his best player but could be tempted by the offer as the three United players would put Spurs in a position to finally qualify for the Champions League.