Manchester City boss Manuel Pellegrini has confirmed that defender Vincent Kompany will be out for at least one month.
The Belgian is expected to play again for the club this season but will miss key games against Manchester United and Paris Saint-Germain in the Champions League.
And with the French giants coming up next month, the Chilean must learn how to find the best odds and lines if he is to succeed where Chelsea failed in the previous round.
"Talking with the doctor, I think that Vincent has an injury in the other calf, not the same one as last time," Pellegrini said.
"We'll see in the way he'll improve – maybe one month he can be ready. I think he could play again this season.
"It's a new injury in the other calf. It's high behind the knee, similar to the one that Kolarov had a month ago and he took three weeks to a month to recover so we'll see.
"it's important to see how he'll improve in the first weeks. The first thing that we think is that within a month he can recover.
"Samir Nasri started working again with the whole squad yesterday. We hope that in the international break the three of them, Delph, Nasri and De Bruyne will play in a friendly with the u21s.
"I think that a derby is always dangerous regardless of the position of both teams – if it's in the Premier League it's doubly dangerous.
"It's hard because they have good players – United have a very good squad, it doesn't matter which play or in which way they play, they're always a dangerous team.
"It's a target [to finish above United] but it's not the most important thing, the most important thing is to finish first, then you're above all other teams. It's a special game and I know the players treat it that way for the fans.
"If you have 24/48 hours more rest, it's important – it's not a decisive thing for the game but you can prepare better. That's the problem with the Europa League as you play on Thursday – it's not easy to prepare.
"[The Champions League?} It's always difficult when you're in the last eight with the best teams in Europe.
"You never know what's an easy draw when you're with the eight best teams on the continent. Maybe one team has less names than another team but they're at this stage so they deserve to be there because they eliminated other teams."