Manchester City boss Manuel Pellegrini says four players are ruled out of Saturday's away game against Crystal Palace.
Midfielder Fabian Delph is expected to be out for six weeks after suffering a hamstring injury in the early stages of England's game against Switzerland.
He joins Pablo Zabaleta and Gael Clichy on the sidelines with David Silva set to be rested after suffering an ankle injury.
"The injury list is [Pablo] Zabaleta, he has a problem with his knee and Gael Clichy," Pellegrini told reporters.
"Also, Fabian Delph has a hamstring injury. Those three and David Silva has a kick in his ankle.
"[David] Silva is out for tomorrow as I think it would be a risk for him to take another knock. I hope he will be OK for Juventus.
"Fabian worked with us before he went to his national squad – he worked without problems and he played some minutes with our team. It's very unlucky to have that injury but it happens.
"I don't know how long Fabian will be out - we'll see. I think at this moment it will be a month and a half.
"[Nicolas] Otamendi is ready to play – he didn't work too much with us as he as away with Argentina.
"Before that, we needed the work permit so he travelled to Spain. His position is more difficult to start playing straightaway but he's 100% and he will play soon."